https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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Using one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our exploration passions include:
It had been only in the nineties though, when nanotechnology had Highly developed to your level the place one molecules could possibly be manipulated, that the main experimental units commenced to appear.
Back in 1991, Sumio Iijima of your NEC Company experienced documented the synthesis of carbon nanotubes. Band structure calculations prompt that these nanotubes could exhibit metallic band conduction. This would be a big benefit over the conducting polymers we experienced explored, which had been, in actual fact, disordered semiconductors giving merely variable-array hopping conductivity.
2007, 1st true-time detection of strand exchange in homologous recombination by RecA; discovery of a minimal persistence size of ends of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is often a extremely versatile protein structure; and to start with detection of DNA knots utilizing nanopores
The coiled-coil of your human Rad50 DNA mend protein consists of unique segments of enhanced versatility
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA restore proteins to DNA translocation through nanopores. A short while ago his exploration has focused on researching cell division with germs on chip, though his best curiosity is in the course of recognizing artificial cells.
Atomic force microscopy displays that vaccinia topoisomerase IB generates filaments on DNA inside of a cooperative style
In 1993, being a youthful and eager associate professor at Delft University of Know-how, I'd at first centered the investigate efforts of my group on measuring the electrical conductance of an individual conducting-polymer molecule. In just two years, we had designed a tool wherein https://www.ceesdekker.net a single wire of a phthalocyaninepolysiloxane polymer was related concerning two closely spaced metal nanoelectrodes.
Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding as being the action-making approach
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Cees Dekker is Distinguished University Professor at TU Delft. Skilled being a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes within the 1990s. Because 2000, he moved to one-molecule biophysics and nanobiology. His latest exploration concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, especially SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker is an elected member of the KNAW and fellow to the APS as well as IOP.
2008, initially observation of protein-coated DNA translocation as a result of nanopores; fixed the origin with the electrophoretic pressure on DNA in nanopores; learned a big velocity enhance of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, plus a 3D rendering of the movement of the DNA rod is shown.